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Symbol Name ID |
Myc
myelocytomatosis oncogene MGI:97250 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal bleeding |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Diffuse alveolar hemorrhage |
Oral cavity bleeding |
Bruising susceptibility |
Purpura |
Ecchymosis |
Petechiae |
Abnormal bone marrow cell morphology |
Abnormal granulocytopoietic cell morphology |
Bone marrow hypercellularity |
Pancytopenia |
Anemia |
Neutropenia |
Decreased proportion of CD4-positive helper T cells |
Leukocytosis |
Leukopenia |
Acute promyelocytic leukemia |
Disseminated intravascular coagulation |
Hypofibrinogenemia |
Thrombocytopenia |
Burkitt lymphoma |
Abnormality of the spleen |
| Disease(s) Associated with MYC | |||||||||||||||||||||||||
| acute promyelocytic leukemia | |||||||||||||||||||||||||
| Burkitt lymphoma |
| Mouse Phenotypes | increased B cell apoptosis |
decreased B cell proliferation |
increased B cell proliferation |
decreased T cell proliferation |
abnormal embryonic erythropoiesis |
enlarged thymus |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal hematopoietic system morphology/development |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
decreased common myeloid progenitor cell number |
absent common myeloid progenitor cells |
abnormal lymphopoiesis |
abnormal T cell receptor beta chain V(D)J recombination |
anemia |
impaired hematopoiesis |
decreased bone marrow cell number |
decreased erythroid progenitor cell number |
absent erythroid progenitor cell |
abnormal proerythroblast morphology |
decreased hematocrit |
increased B cell number |
increased pre-B cell number |
decreased NK T cell number |
decreased memory T cell number |
decreased T cell number |
increased lymphocyte cell number |
increased macrophage cell number |
increased leukocyte cell number |
spleen hypoplasia |
abnormal NK cell physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||
| Myctm1Atp/Myctm1Atp | ||||||||||||||||||||||||||||||||||
| Myctm1Jlc/Myctm1Jlc | ||||||||||||||||||||||||||||||||||
| Myctm1Lbox/Myctm1Lbox | ||||||||||||||||||||||||||||||||||
| Tg(HBVX*,-Myc)#Skp/Tg(HBVX*,-Myc)#Skp | ||||||||||||||||||||||||||||||||||
| Myctm1Atp/Myc+ | ||||||||||||||||||||||||||||||||||
| Myctm1Atp/Myctm2.1Atp | ||||||||||||||||||||||||||||||||||
| Myctm1Lbox/Myc+ | ||||||||||||||||||||||||||||||||||
| Myctm2.1Atp/Myc+ | ||||||||||||||||||||||||||||||||||
| Myctm3(Tcrb)Fwa/Myc+ | ||||||||||||||||||||||||||||||||||
| Tg(HBB-Myc)#Cos/0 | ||||||||||||||||||||||||||||||||||
| Tg(IghMyc)22Bri/0 | ||||||||||||||||||||||||||||||||||
| Tg(Pklr-Myc)73Ak/0 | ||||||||||||||||||||||||||||||||||
| Tg(IghMyc)22Bri/? | ||||||||||||||||||||||||||||||||||
| Myctm2.1Atp/Myctm2.1Atp Edil3Tg(Sox2-cre)1Amc/Edil3+ (conditional) |
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| Myctm2.1Atp/Myctm2.1Atp Tg(Tek-cre)1Rwng/0 (conditional) |
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| Myctm2Fwa/Myctm2Fwa Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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